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It is generally the case that Knoppix is used as a LiveCD LiveUSB,
or in a poor-man's HDD install,
where Debian is more often used in a 'permanent' HDD install.

Knoppix is probably the best...

Greetings, routaran.

Here is a somewhat dated reference you might consult:
http://en.wikibooks.org/wiki/A_Neutral_Look_at_Operating_Systems/Linux#Knoppix

You will only have a good answer to...