Check out the home pages on the NTFS drivers. Their problems tend to be with permissions/ownership of files and allocation of space if writing a new file. With few or hard choices with a Windows system, I would delete files with little anxiety; rewrite deloused files with little anxiety unless they expand radically, which I would view as unlikely, and I would be apprehensive about writing a new file. You can write a backup within KNOPPIX to a USB or firewire drive. If Windows ran afterwards, I would create a proper backup of all data, in case of a crash.
I would view the O/S as suspect, but then it is a Windows system and suspect to begin with. I have a blow it all away and reload about once a year on my machines. It usually involves one intensive session and then a week or so of intermittant tinkering to get everything reloaded and all of the data retrieved from backups i.e. to get everything arranged. I am more conservative with the machine my wife is on, because she doesn't respond well to needing a piece of software reloaded or some data file retrieved from a backup. I keep good backups of that box and pray a lot. It is an older box 1 Ghz with W2K. I have been unsuccessful in persuading her to move to a notebook.
Cisco Catalyst C9300-24UX-A 24 Port 10G/mGig Copper UPOE Network Switch
$475.00
Cisco STACK-T4-3M for C9200/9200L 3M Stacking Cable New
$181.57
Cisco Catalyst WS-C2960X-24PD-L GigE PoE 370W, 2 x 10G SFP+, LAN Base H22
$94.00
Cisco WS-C2960X-48FPD-L 48 V07 POE+ GE+2 10G SFP+, LAN BASE 740W w/ C2960X-Stack
$110.00
🔥🔥🔥 CISCO SFP-10G-SR V03 10-2415-03 850nm 10GBASE-SR SFP+ Multi Module 🔥🔥🔥
$6.80
Cisco C3850-NM-2-10G 2 Port Network Exp.Module for 3850
$30.99
GENUINE Cisco SFP-10G-SR V03 SFP+ GBIC Transceiver Module 10-2415-03
$6.80
Genuine Cisco ‎SFP-10G-SR Transceiver Module (10-2415-03)
$5.85
Cisco C9200L-STACK-KIT Stacking Kit New Sealed
$435.57
Cisco Nexus N9K-C92160YC-X 48P 25GbE SFP28 6P QSFP+/QSFP28 PE Switch
$499.00