Knoppix may be run with several desktops, and GNOME and KDE can be chosen with the desktop cheatcode. After the introduction of LXDE, there does, however not seem to be so much interest in other lightweight alternatives.
What about using Enlightenment and the EFL (Enlightenment Foundation Libraries)? This is used in a Ubuntu derivative called Bodhi Linux, and some users seem to be very content - it's seemingly not the best for newbies, though.
What makes Enlightenment particularly interesting to me, is that it is the preferred desktop alternative for the Tizen project for full-version Linux on mobile devices (as opposed to the kernel+Android stack approach) This is Debian-based, and shouldn't really be that far from Knoppix, porting Knoppix to mobile devices should become easier with every day now.
Using Enlightenment with Knoppix could provide one of the stepping stones to mobile Knoppix, or is this approach futile?
Without having asked about this, I guess KK's first answer will be negative. Knoppix is extremely hardware agnostic, but achieves that by sticking to hardware based on x86 architectures, and keeps the 32-bits approach. Not even a 64-bits version is in sight (if things haven't changed lately), and I have come to support his approach, IMHO it's very practical to chroot into a 64-bits system from hybrid Knoppix and doing everything purely 64 bits there.
This 32/64-bits situation will relatively soon be parallelled in the mobile scene, making the whole situation even more convoluted.
It will be very interesting to see how the Tizen project develops - but there will actually be several Debian-based mobile alternatives. A Ubuntu version was recently announced, and you can already download an alpha release of Bodhi for the Asus Nexus 7 tablet. The Knoppix take on this might be to adapt a minirt.gz for mobile devices, which I guess will have to be tweaked separately for each new device in the first place.
With 2-4GB of RAM and 16-32GB of internal storage on the upcoming devices, there should be room for a Knoppix compressed image+persistent store without wiping out anything else, setting up for multi-boot.
Ineo USB 3.1 Gen 2 Type C Dual Bay 3.5 inch SATA Raid Enclosure TESTED but READ
$30.00
ORICO 5Bay Raid Hard Drive Enclosure USB3.0 to SATA for 3.5'' HDD SSD 150W Power
$155.99
Kingwin Drive Enclosure Internal 3 Bay Hot Swap Mobile Rack SATA SAS TESTED
$22.00
Intel VROC NVMe RAID standard upgrade HW key (RSTe) VROCSTNMOD Dell 7820 7920
$60.00
PCI to 4 Ports SATA Controller RAID CARD Pci sata Sil3114 Supports 3TBx4 HDD
$15.99
4 Ports PCI SATA Raid Controller Internal Expansion Card
$14.50
Adaptec - ASR-7805 6Gbs SAS- PCI EXPRESS 3.0 X8 -1GB Cache RAID Controller Card
$24.99
PCI To 2 Port SATA RAID Controller Card Sil3112 chipset SATA PCI Controller Card
$13.98
ORICO 5 Bay Raid USB3.0 to SATA External Hard Drive Enclosure for 3.5'' HDD US
$125.99
Xcellon DRD-101 Dual Bay Raid System For 3.5" SATA HDDs Used Untested
$44.95