hey guys...I'm a newbie in knoppix linux..I liked it so much...i have a question by the way...

can i make a application software run on my knoppix OS but the thing is, the application is installed in my windows file system or windows??can i?
can you teach me guys...
i tried to click the .exe file then opened it with WINE...but it wont work...is there any way that i get it to work???please...