Quote Originally Posted by Harry Kuhman
I should point out my interest is entirely in running a live CD
Then I see no reason for you to switch unless:
A) Kanotix supports hardware that Knoppix doesn't. (like acpi )
B) You like the installed applications of Kanotix over those of Knoppix.
C) You would like to help with the big hunt!

Kanotix was made for an hdd installation but most certainly does use the knoppix autodetection for hardware.