If you have done a full HD install (ie not a 'poormans install'), no, you shouldn't have to save any configs or home files. One 'exception' (which isn't really an exception) if you have done a Knoppix style install & want to maintain changes to /etc/fstab, you will have to add 'nofstab' to your 'append=' line in lilo.conf so fstab won't get overwritten with each boot.