I've tried running KNOPPIX_V3.7-2004-12-08-EN.iso from CD, more than once but after about 1/2 an hour, during which my hardware is detected, it gets as far as the splash-screen with the Penguin sitting in the middle of a CD, then nothing.

System specs:
OS: Win. XP Pro.
File System: NTFS
MB: ASUS A7N8X-E Deluxe
BIOS: Award
CPU: AMD Athlon XP 1.6
Ram: 256 Meg Crucial Memory
HD: C80GB Western Digital Caviar SE, no partitions)
CD Drive: DLiteon 40x12x48x Writer)
DVD Drive: JLG GSA-4160B Writer, in external USB2 enclosure)

Ajak.