I was able to get it working in Mepis (sorta) after some work.
The following entry from the klik forums was helpfull
http://www.knoppix.net/forum/viewtopic.php?t=16904 look for the entry by lilsirecho.
By following the suggestion of creating the mount directory and the mount command I was able to execute the wrapper command to get it working.

Example
I downloaded the lphoto2 klik
created the directory /mnt/app/1
ran
mount-t cramfs -o loop ~/Desktop/lphoto2.cmg /mnt/app/1
cd /mnt/app/1
./wrapper

It ran.

I noticed if that I created the directories and then ran a klik it removed the directories that I created .
I'm trying to see what the underlying problem is but am fairly new to bash so it's slow going.

Hope this helps


Found the problem
It appears that SimplyMepis 3.3 does not like the auto in the fstab for cramfs type klik images. If I change the type from auto to cramfs it appears to run w/o problems. I'll do more investigation but that is what it looks like to me.