I had the same problem.

The mouse can move the cursor fine, the scroll wheel even works fine but whatever i do knoppix refuses to respond to mouse clicks anywhere.

My mouse is a wireless USB optical mouse from Hewlet Packard, on a HP Pavilion machine.

Knoppix says it recognizes the mouse during startup.

Windows describes the mouse as: HID-compliant mouse.

My Knoppix version is 3.6, I have just Downloaded 3.9 to see if it works on that.

Thanks for any help anyone can provide.