Knoppix will run on your system. But if you want to set up a server and you want to install it on a hard disk, you don't need or want much of the stuff that comes with Knoppix. You may not even want a GUI, and certainly not KDE that comes with Knoppix, just a command line interface. Since you are tinking about installing it to a hard drive, why not install Debian (the distro of Linux that Knoppix is made from) instead? That way you will avoid all of the mixed version issues that are seen with knoppix and you'll be able to just install the applications that you really want. You wouldn't have to try to remove anything that you didn't want since you will not have installed it in the first place.