Sure.
By default Knoppix will look/scan the HDs to see if it contains partitions. If the HDs do have partitions, Knoppix will automatically build a '/etc/fstab' file and fill-in the appropriate partition entries and will also create the '/mnt/hdxx' mount points. The 'nofstab' cheat code prevents this look/scan and prevents the generation of the /etc/fstab and its mount points.

Reasons why someone might use 'nofstab':
*HD is brand new & no partitions. Not necessary to scan it.
*User plans to do HD/partition maintenance. Do not want /etc/fstab & mount points to be created.
*Combine 'nofstab' with 'noswap' to force Knoppix to not even touch a HD. Again useful for HD/partition maintenance but also for data recovery and forensics.

Usage of the nofstab cheat code will probably break the userfriendly desktop HD icons since they rely on the the automatic config of both fstab & the mount points.