I seem to be having a similar problem. Using the DE knoppix 4.0 DVD (with knoppix lang=en) my 'MICROSOFT Wireless Optical Mouse' works but when I got the EN 4.0 DVD my mouse wouldn't work; since I upgraded to 4.02 DVD both the DE and the EN version do not detect my mouse. Interesting no? I have not tried any of the cheat codes for 'fixing' mouse problems ... yet