certainly in part.
atleast with a Debian install.
You most certainly will get them working without Knoppix with a bit of tinkering.
what exactly is the problems?
the Xwindow environment settings are in /etc/X11/Xorg.conf or /etc/X11/Xfree86.conf (depending on distribution)
the Sound drivers? should be pretty much the same regardles of distribution, what exactly was the problem there?
as to network... what do you need?