Knoppix doesn't care about Vista, it will run on systems with no hard drive at all. It's some other issue. You might need a cheat code. You might have burned the disc at high speed and ended up with a disc that will work on some drives and not others. It might be something else that I'm not even thinking about at the moment. We do occasionally see that error reported without ever getting a good report back on what caused it. But you're on the wrong track with it Vista being an issue. I suggest reading the downloading FAQ and, if the disc was burnt at high speed try a slower burn, and if you have a different brand of media available I would try that at the same time just in case. Beyond that, read the cheat codes text file that came down with your download.