please, realise this is a forum where we woulonteer information, so replies can be slightly slow in coming.

NTFS can be READ! but not safely written to, also FAT32 has max filesize of 3.99G this is bit limited.
Linux (unix) filesystems (EXT3 to name a very common one) can be used to store single files in several hundreg G size if I remember correct.
also EXT3 can be read with Windows if you install correct driver.

OH, and you will loose everything on that disc if you format.

EDIT
HEH, ndb, seem to have posted similar answers at same time
/EDIT