I have just started trying out 64 bits 6.4.4 myself, and initial impressions are very good. WIFI worked out of the box etc. But I think there may be some setup modifications necessary, for instance in the KNOPPIX/modules directory: That is initially empty in 6.4.4, but, for instance for ext4 support, I think ext4.ko must reside there. Both 32 and 64 bits versions of the module are called ext4.ko. Could such issues be resolved by adding a 64-bits directory somewhat similar to the lib/modules structure?

Code:
/KNOPPIX/lib/modules/2.6.37/kernel/fs/ext4/ext4.ko
/KNOPPIX/lib/modules/2.6.37-64/kernel/fs/ext4/ext4.ko
I also wonder if I will run into problems with the 64 bits version of vmware. Anyone with experience with this?