...I have successfully run as a persistent USB flash drive. And this is only because it come with it's own built in "Install to Flash Disk" utility.

I've messed with "Linux Mint", Debian, Ubuntu with various levels of success. If I did get it working, it wasn't very stable. Doing this by following step-by-step instructions or by using a tool like Universal-USB-Installer.

Being able to take your computing environment to any computer (that can boot from USB) is a very attractive alternative.

Keep up the good work! Looking forward to the next Knoppix with even more persistent USB options. It would be cool if it could run from USB and be no different then if it were running from hard drive.