I've been experimenting with Knoppix (version 3.3, I think) and it's very impressive.
This is a summary of how I got my P166-MMX with a trackball on /dev/ttyS1 to work with Knoppix.
At the boot prompt I enter: knoppix 2 lang=us desktop=xfce nousb nopcmcia.
Apparently Knoppix doesn't like serial mice. Starting at run level 2 allows a user to run gpmconfig, and also
permits you to access a text editor (I use mcedit) to change the /etc/X11/XF86Config-4 file so that X will recognize your mouse.
I tried using the expert boot option, but changing the mouse settings that way didn't work.
The following steps could be done in an xterminal, although I prefer to do them before an X session.
Once Knoppix is loaded, to enable my modem I type:
setserial /dev/ttyS? irq #
Replacing the ? and # with the appropriate numbers. Later, I'll setup the actual connection using the tools in X.
To set up printing using CUPS:
/etc/init.d/apache start
/etc/init.d/cupsys start
Now I can type:
lynx localhost:631
to configure my printer, or I can go to X and point Mozilla/Konqueror at localhost:631.
Now for the best part: Loading kernel modules.
I discovered that there are quite a few kernel modules available with Knoppix. to see them, type:
modconf
and you'll see the list.
The ones I'm especially interested in are the iptables/packet filtering modules, the parport module, and
the sg and ppa scsi driver modules for using an older Iomega zip drive.
What I'm going to do is load the modules I want, then copy them from /lib/modules to /mnt/floppy, so I can have them available when and if I need them.
Almost forgot: If you haven't gone into X yet, you can get there by typing:
startx
or:
xinit
if you're a purist.

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