I think that you should create a small file /home/knoppix/.config/autostart/lxdeDefaultScreenlayout.desktop with the following content:
Code:
[Desktop Entry]
Name=lxdeDefaultScreenlayout
Type=Application
Exec=sudo /usr/local/bin/lxdeDefaultScreenlayout
Terminal=false
The owner of the .desktop file should be knoppix.

There is a thread 'How to autorun a X program' where you can find a link to the 'Desktop Entry Specification'.